Tuberculosis

Tuberculosis (TB) is the world’s leading infectious disease killer, responsible for 1.6 million deaths a year. New tests, medicines, and preventive therapies can turn the tide on TB, but their impact will be limited if we do not urgently address the access barriers that stand in the way of getting these lifesaving health products to the people who need them.

10 million

More than 10 million people fell ill with TB in 2022

3 million

Each year, 3 million people with TB go undiagnosed and untreated

2 out of 3

children with TB are never diagnosed and nearly all those who die were never treated

400000

400,000 people have drug-resistant TB but only 2 in 5 access treatment

The problem

Children have been neglected

Though children are highly vulnerable to TB infection, their care has been largely neglected. Diagnostic tests, built to detect TB in adults, are often ineffective in children and a lack of systematic screening of sick children for TB risk factors leaves many children undiagnosed and therefore, never treated.

When a child does receive a diagnosis, insufficient information on medicine dosage and easy-to-swallow child formulations complicated child TB treatment for decades. And effective prevention regimens – which can clear TB infection before illness develops – are not reaching millions of children who are at risk.

The lack of a simple, effective, same-day diagnostic test for TB, available at the primary health care level, means that many people never get a diagnosis, never access treatment, and the disease continues to spread. Diagnosing drug-resistant TB is even more challenging, costly and slow. Untreated, a person with TB can spread the disease to 10-15 others in a year.

Though treatment options have radically improved in the past decade, TB treatment still takes months, requires frequent clinic visits and can cause difficult side effects. This can lead people to abandon treatment, which can cause the illness to return and can contribute to drug resistance.

Though preventive treatments can clear a TB infection before it develops into active disease, many people at highest risk still do not have access. Widespread contact tracing is needed to reach vulnerable groups, such as children or others who have been exposed to the infection, with effective preventive care.

Game-changing innovations
Our goal is to identify the most needed solutions to prevent, diagnose and treat TB and help get them off the ground so they can be rolled out widely. Below are a few examples of the innovations we are supporting.
Targeted next-generation sequencing for TB diagnosis
Provide a rapid and comprehensive way to identify TB drug-resistance.
TB medicines for children
Strawberry-flavored, water-soluble medicines that make TB treatment easier for children and their care givers.
Shorter TB prevention regimens (3HP/1HP)
Best-in-class TB preventive regimens lasting one or three months, now available in low- and middle-income countries at 20% their original price.
More tolerable treatments for drug-resistant TB
Effective, affordable, and less toxic treatment alternatives for people with drug-resistant TB.

Our response

We are committed to ensuring that new TB medicines can benefit everyone, preventive treatments reach the most at-risk populations, and TB testing is quick, accurate and accessible where it is needed most.